TABLE 4.
Factors associated with MACEs.
| Variable | HR | 95% CI | p-value |
|---|---|---|---|
| Age (per year) | 1.09 | 1.04–1.14 | 2.2 × 10−14 |
| Male gender (yes versus no) | 1.58 | 1.08–2.08 | 0.0079 |
| Hypertension (yes versus no) | 3.11 | 2.10–4.25 | 6.9 × 10−6 |
| Diabetes (yes versus no) | 2.44 | 1.46–3.52 | 0.0021 |
| Smoking (yes versus no) | 2.56 | 1.56–3.18 | 0.00041 |
| LDL cholesterol level (per 10 mg/dl) | 1.01 | 1.00–1.02 | 0.022 |
| Prior CVD (yes versus no) | 3.45 | 2.02–4.80 | <2.2 × 10−16 |
| Missense variants (versus no pathogenic variants) | 1.58 | 1.08–2.08 | 0.0033 |
| PTVs (versus no pathogenic variants) | 3.24 | 2.12–4.40 | 3.9 × 10−6 |
HR, hazard ratio; CI, confidence interval; CVD, cardiovascular disease; PTV, protein-truncating variants; LDL, low-density lipoprotein.