TABLE 1.
Characteristics of the Study Cohort* for Patients With Stool and Plasma Samples
| Stool | Plasma | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| HDC | MAH | SAH | P Value | HC | HDC | MAH | SAH | P Value | |
| Number of participants | 20 | 8 | 21 | 20 | 12 | 11 | 16 | ||
| Age (years), mean (SD) | 46.39 (13.63) | 54.33 (7.09) | 43.21 (11.36) | 0.089 | 39.85 (11.32) | 36.50 (13.45) | 51.19 (9.57) | 48.85 (6.76) | 0.008 |
| Sex (%) | 0.148 | 0.767 | |||||||
| M | 12 (60.0) | 7 (87.5) | 10 (47.6) | 10 (50) | 8 (66.7) | 7 (63.6) | 10 (62.5) | ||
| F | 8 (40.0) | 1 (12.5) | 11 (52.4) | 10 (50) | 4 (33.3) | 4 (36.4) | 6 (37.5) | ||
| Race (%) | 0.421 | 0.187 | |||||||
| White | 18 (90.0) | 7 (87.5) | 21 (100) | 19 (95.0) | 9 (75.0) | 8 (72.7) | 15 (93.8) | ||
| Black or African American | 1 (5) | 1 (12.5) | 0 (0) | 0 (0) | 2 (16.7) | 3 (27.3) | 1 (6.2) | ||
| Asian | 0 (0) | 0 (0) | 0 (0) | 1 (5) | 0 (0) | 0 (0) | 0 (0) | ||
| More than one race | 1 (5) | 0 (0) | 0 (0) | 0 (0) | 1 (8.3) | 0 (0) | 0 (0) | ||
| BMI, mean (SD) | 29.56 (7.51) | 26.92 (2.60) | 28.35 (6.09) | 0.673 | 26.81 (6.46) | 25.08 (6.73) | 25.02 (3.82) | 27.67 (5.95) | 0.594 |
| Average number of drinks per day, mean (SD) | 17.32 (13.42) | 16.40 (13.71) | 12.44 (9.13) | 0.434 | — | 11.45 (8.30) | 6.90 (3.95) | 7.35 (4.21) | 0.110 |
| Hemoglobin (g/dL), mean (SD) | 13.21 (1.43) | 9.84 (1.82) | 10.36 (1.90) | <0.001 | 13.97 (1.61) | 11.86 (2.59) | 10.00 (2.34) | 9.78 (2.39) | <0.001 |
| AST ( U/L), mean (SD) | 25.00 (8.27) | 158.20 (91.16) | 114.50 (44.97) | <0.001 | 83.33 (171.40) | 28.27 (11.91) | 141.70 (97.87) | 109.56 (29.47) | 0.036 |
| ALT (U/L), mean (SD) | 25.11 (12.36) | 63.20 (42.86) | 40.40 (21.07) | 0.002 | 36.89 (34.44) | 21.18 (9.87) | 44.30 (23.37) | 49.31 (55.93) | 0.308 |
| Bilirubin (mg/dL), mean (SD) | 0.44 (0.27) | 7.06 (3.76) | 19.57 (11.36) | <0.001 | 0.62 (0.49) | 0.55 (0.47) | 4.88 (2.60) | 17.16 (9.64) | <0.001 |
| Albumin (g/dL), mean (SD) | 4.06 (0.52) | 2.66 (0.15) | 2.82 (0.52) | <0.001 | 4.36 (0.24) | 3.55 (0.63) | 2.74 (0.51) | 2.78 (0.61) | <0.001 |
| WBC (×109 cells/L), mean (SD) | 6.75 (2.69) | 13.74 (8.70) | 16.56 (12.83) | 0.008 | 7.18 (1.66) | 9.00 (3.34) | 9.89 (6.58) | 10.05 (5.12) | 0.451 |
| Platelets (×109/L), mean (SD) | 265.89 (52.83) | 207.60 (175.51) | 155.00 (88.64) | 0.002 | 258.33 (89.63) | 287.36 (146.47) | 145.90 (83.98) | 154.94 (88.92) | 0.003 |
| Creatinine (mg/dL), mean (SD) | 0.89 (0.35) | 0.67 (0.31) | 1.09 (0.71) | 0.257 | 0.89 (0.16) | 0.83 (0.41) | 0.74 (0.20) | 0.93 (0.54) | 0.652 |
| INR, mean (SD) | 1.00 (0.15) | 1.37 (0.20) | 2.07 (0.40) | <0.001 | — | 1.13 (0.23) | 1.50 (0.41) | 2.04 (0.45) | <0.001 |
| MELD score, mean (SD) | 7.37 (1.74) | 14.62 (3.85) | 26.81 (5.32) | <0.001 | — | 8.50 (3.50) | 15.73 (4.22) | 25.38 (3.93) | <0.001 |
| Child‐Pugh score, mean (SD) | 5.21 (0.43) | 9.00 (0.71) | 10.45 (1.64) | <0.001 | — | 5.70 (0.67) | 8.70 (1.70) | 10.31 (1.74) | <0.001 |
| DF score, mean (SD) | 12.54 (8.79) | 35.95 (7.00) | 81.33 (31.75) | <0.001 | — | ‐2.60 (11.66) | 22.04 (20.72) | 59.31 (21.56) | <0.001 |
*
6 patients had both stool and plasma samples.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; DF, discriminant function; F, female; INR, international normalized ratio; M, male; WBC, white blood count.