TABLE 1.
Baseline Demographic, Metabolic, Laboratory, Histologic, and Genetic Features of Entire Cohort Stratified For Low Risk of Fibrosis (FIB‐4 < 1.3) and Intermediate/High Risk of Fibrosis (FIB‐4 ≥ 1.3)
| FIB‐4 < 1.3 (n = 3 17) | FIB‐4 ≥ 1.3 (n = 229) | P Value | |
|---|---|---|---|
| Mean age, years | 43 ± 12.3 | 61.6 ± 9.1 | <0.001 |
| Age ≥ 50 years | 34.1% | 90.8% | <0.001 |
| Male sex | 70% | 56.8% | 0.001 |
| Mean BMI | 29.74 ± 5 | 31.8 ± 5.7 | 0.34 |
| Obesity (BMI ≥ 30 kg/m2) | 40.1% | 61.6% | <0.001 |
| Blood glucose, mg/dL | 98.9 ± 33.3 | 113.8 ± 35.4 | 0.01 |
| Total cholesterol, mg/dL | 200 ± 43.4 | 180.2 ± 48 | 0.32 |
| HDL, mg/dL | 49.2 ± 13.9 | 48.8 ± 16.9 | 0.03 |
| HDL <40 mg/dL in males | 33.1% | 38.4% | 0.20 |
| <50 mg/dL in females | |||
| Triglycerides, mg/dL | 146 ± 97.5 | 131 ± 63.1 | 0.004 |
| Triglycerides ≥ 150 mg/dL | 36.9% | 28.4% | 0.03 |
| AST, IU/L | 39.5 ± 20.2 | 49.1 ± 31.6 | 0.001 |
| ALT, IU/L | 78.1 ± 53.1 | 57.9 ± 41 | 0.02 |
| Albumin, g/L | 4.6 ± 0.3 | 4.2 ± 0.4 | <0.001 |
| Albumin ≥ 4 g/L | 3.1% | 25.3% | <0.001 |
| PLTs, 103/mm3 | 262.6 ± 77.7 | 160.3 ± 67.2 | <0.001 |
| PLTs ≥ 110 × 103/mm3 | 0 | 21.4% | <0.001 |
| Type 2 diabetes | 22.7% | 57.6% | <0.001 |
| Arterial hypertension | 29.3% | 58.5% | <0.001 |
| Statin users | 17.9% | 24.0% | 0.11 |
| Metformin users | 30.0% | 27.9% | 0.68 |
| PNPLA3 rs738409 CC/CG/GG | 35/45.7/19.2% | 25.8/46.3/27.9% | 0.01 |
| TM6SF2 rs58542926 CC/CT/TT | 72.5/24.3/2.2% | 72.9/24.4/2.6% | 0.95 |
| HSD17B13 rs72613567 T/TA/TATA | 65.6/30.6/3.8% | 74.2/22.7/3.1% | 0.09 |
| Time of follow‐up, months | 79.4 ± 42.9 | 66.1 ± 37.3 | 0.03 |
Data are given as mean ± SD or as percentage (%) of cases.