TABLE 2.
Multivariate Cox Regression Analysis of Clinical, Metabolic, and Genetic Variables Associated With LREs in Patients With NAFLD With FIB‐4 ≥ 1.3
| HR (95% CI) | P Value | |
|---|---|---|
| Male sex | 1.52 (0.76‐3.06) | 0.23 |
| Age 55‐65 years | 13.96 (2.90‐67.23) | 0.001 |
| Age > 65 years | 17.96 (3.66‐88.12) | <0.001 |
| PLTs 110,000‐150,000/mm3 | 6.89 (2.74‐17.35) | <0.001 |
| PLTs < 110,000/mm3 | 13.54 (5.53‐33.13) | <0.001 |
| Albumin <4 g/L | 1.95 (1.00‐3.78) | 0.04 |
| Low HDL | 1.88 (1.02‐3.44) | 0.04 |
| Diabetes | 0.66 (0.32‐1.38) | 0.27 |
| PNPLA3 rs738409 | 0.64 (0.18‐2.28) | 0.49 |
| HSD17B13 rs72613567 | 1.83 (1.07‐3.43) | 0.04 |
| TM6SF2 rs58542926 | 1.94 (1.00‐3.77) | 0.04 |
| PNPLA3 × sex | 0.32 (0.10‐0.98) | 0.04 |
| PNPLA3 × diabetes | 5.16 (1.30‐20.41) | 0.01 |