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. 2021 Dec 28;6(5):1100–1112. doi: 10.1002/hep4.1881

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© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG. 2 — Pathway enrichment analysis, including the metabolites differentially expressed in patients with ACLF compared to patients with decompensated cirrhosis without ACLF. A significant enrichment for several metabolic pathways was identified for these metabolites (P < 0.05). The y axis represents the P value; the x axis represents the pathway impact (pathways more likely to be modified in ACLF compared with decompensated cirrhosis without ACLF). Node color is based on the P value (red indicates a higher level of significance), and node radius is based on the pathway impact value. Metabolites increased in ACLF versus decompensated cirrhosis without ACLF.