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. 2021 Dec 28;6(5):1100–1112. doi: 10.1002/hep4.1881

FIG. 5.

FIG. 5

Pathway enrichment analysis, including the metabolites differentially expressed in ACLF in patients treated with simvastatin plus rifaximin compared to those in patients treated with placebo in the intervention cohort. The y axis represents the P value; the x axis represents pathway impact (pathways more likely to be modified in ACLF compared with decompensated cirrhosis without ACLF). Node color is based on the P value (red indicates higher level of significance), and node radius is based on the pathway impact value. A significant enrichment for several metabolic pathways was identified for these metabolites (P < 0.05).