. 2021 Dec 10;6(5):935–949. doi: 10.1002/hep4.1875

TABLE 1.

Predictors of HBsAg loss in HBeAg‐negative patients

Source	Country	N	Age (Mean)	Male (%)	NA Used	Follow‐up (Weeks)	HBsAg Loss (%)	Predictors of HBsAg Loss
Berg et al.⁽ ⁴⁹ ⁾	Germany	42	45	33	TDF	144	10	N/A
Jeng et al.⁽ ⁵² ⁾	Taiwan	691	52	86	ETV, TDF, ADV, LMV	2‐614	6.1	Time to undetectable HBV DNA < 12 weeks
								HBsAg reduction > 1 log₁₀ IU/mL
								HBsAg level < 100 IU/mL at EOT
Hung et al.⁽ ⁵⁹ ⁾	Taiwan	73	52	78	LMV, ETV, TBV	48‐288	27.4	HBsAg level at EOT
								HBsAg decline from baseline to EOT
								Discontinuing vs. continuing NA
Papatheodoridi et al.⁽ ⁵⁷ ⁾	Greece	57	60	65	ETV, TDF	76	21.5	HBsAg level at EOT
								ALT level at month 1
								IP10 level at month 1
								HBsAg level at month 1
Yao et al.⁽ ⁵⁸ ⁾	Taiwan	119	52	79	LMV, ETV	48‐312	37	HBV genotype C vs. B
Yao et al.⁽ ⁵⁸ ⁾	Taiwan	119	52	79	LMV, ETV	48‐312	37	HBsAg level at EOT
Liem et al.⁽ ⁵¹ ⁾	North America	45	49	58	TDF, ETV	72	2.2	N/A

Abbreviations: EOT, end of treatment; IP10, IFN‐γ‐induced protein 10; N/A, not applicable.