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. 2022 Apr 11;9:848463. doi: 10.3389/fmolb.2022.848463

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Copyright © 2022 Chen, Meng, Yan, Wang, Jiang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing TK1 relieves inflammatory response and apoptosis in SLE BMSCs. (A) TK1 mRNA expression was measured in SLE BMSCs with TK1 overexpression or TK1 knockdown through RT-qPCR. (B,C) TK1 protein expression was tested in SLE BMSCs with TK1 overexpression or TK1 knockdown via western blotting. (D) IL-1β levels were quantified in the supernatant of specified SLE BMSCs through ELISA. (E) RT-qPCR was adopted to measure the mRNA expression of IL-1β in specified SLE BMSCs. (F,G) Flow cytometry analyses were conducted to test the apoptosis levels of specified SLE BMSCs. **p < 0.01; ***p < 0.001; ****p < 0.0001.