Table 3.
Univariate and multivariate logistic regression analysis of ICC presence based on preoperative data in training cohort.
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| Age (years) | 1.02 (1.01, 1.04) | 0.003 | NA | |
| Sex | <0.0001 | |||
| Male | reference | reference | ||
| Female | 2.73 (2.05, 3.63) | NA | ||
| PLT (109/L) | 1.01 (1.01, 1.01) | <0.0001 | NA | |
| RBC (1012/L) | 0.72 (0.58, 0.88) | 0.0012 | NA | |
| WBC (109/L) | 1.24 (1.18, 1.31) | <0.0001 | NA | |
| Log AFP (ng/ml) | 0.24 (0.19, 0.30) | <0.0001 | 0.47 (0.32, 0.69) | 0.0001 |
| Log AFP-L3% | 0.35 (0.30, 0.42) | <0.0001 | NA | |
| Log CEA (ng/ml) | 5.46 (3.92, 7.62) | <0.0001 | NA | |
| Log CA125 (U/ml) | 4.35 (3.28, 5.77) | <0.0001 | 2.74 (1.50, 5.01) | 0.001 |
| Log CA199 (IU/ml) | 7.68 (5.90, 9.98) | <0.0001 | 2.88 (1.95, 4.25) | <0.0001 |
| Log PIVKA-II (mAU/ml) | 0.20 (0.16, 0.26) | <0.0001 | 0.19 (0.13, 0.30) | <0.0001 |
| Log AST (U/L) | 1.02 (0.69, 1.53) | 0.9105 | NA | |
| Log ALT (U/L) | 1.12 (0.80, 1.57) | 0.5168 | NA | |
| TP (g/L) | 0.99 (0.97, 1.00) | 0.106 | NA | |
| ALB (g/L) | 0.98 (0.96, 1.00) | 0.0927 | NA | |
| Log GGT (U/L) | 3.32 (2.53, 4.36) | <0.0001 | NA | |
| Log TBIL (μmol/L) | 3.69 (2.60, 5.24) | <0.0001 | NA | |
| Log DBIL (μmol/L) | 2.82 (2.17, 3.66) | <0.0001 | NA | |
| HBV | <0.0001 | <0.0001 | ||
| No | reference | reference | ||
| Yes | 0.05 (0.03, 0.06) | 0.13 (0.08, 0.22) | ||
| HCV | 0.1516 | |||
| No | reference | reference | ||
| Yes | 0.49 (0.19, 1.30) | NA | ||
Categorical variables are expressed as frequency. Continuous variables are expressed as mean (SD) or median with interquartile range (IQR).
PLT, platelet; RBC, red blood cell; WBC, white blood cell; AFP, α-fetoprotein level; AFP-L3, an isoform of AFP characterized by the presence of an a 1–6-linked residue on the AFP carbohydrate side chain; CA199, carbohydrate antigen 199; CEA, carcinoembryonic antigen; PIVKA-II, protein induced by vitamin K absence or antagonist-II; CA125, carbohydrate antigen 125; ALT, alanine transaminase; AST, aspartate transaminase; GGT, gamma glutamyl transpeptidase; TP, total protein; ALB, albumin; TBIL, total bilirubin; DBIL, direct bilirubin; HBV, hepatitis B virus; HCV, hepatitis C virus; NA, Not applicable.