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. 2022 Apr 12;22:100461. doi: 10.1016/j.bbih.2022.100461

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Effects of restraint stress on expression of cellular senescence markers p16^INK4a and p21 in mouse bone marrow cells.

(a) Five-number summary box plot of expression of cellular senescence marker p16^INK4a (Cdkn2a; winsorized at 90/10th percentile) in bone marrow cells of mice randomized to Control (n = 10), Restraint (n = 10), or Propranolol (Prop) + Restraint (n = 6) conditions on a log2 scale centered at zero. (b) Box plot as in (a) of expression of cellular senescence marker p21 (Cdkn1a). ∗p < .05, ∗∗p < .01, ∗∗∗p < .001 vs. Control.