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. 2022 Apr 12;22:100461. doi: 10.1016/j.bbih.2022.100461

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Effects of restraint stress on the DNA repair transcriptome and SASP transcriptome in mouse bone marrow cells.

(a) Five-number summary box plot of composite scores of the DNA repair transcriptome (winsorized at 90/10th percentile) in bone marrow cells of mice randomized to Control (n = 10), Restraint (n = 10), or Propranolol (Prop) + Restraint (n = 6) conditions on a log2 scale centered at zero. Reference set for DNA repair genes was bioinformatically identified and empirically validated by Collin et al. (2018). Heatmap of mean fold-changes for distinct DNA repair genes in Restraint and Prop + Restraint vs. Control group on log2 scale. (b) Box plot as in (a) of composite scores of senescence-associated secretory phenotype (SASP) transcriptome (winsorized at 90/10th percentile) and heatmap of mean fold-changes for distinct SASP genes. ∗p < .05, ∗∗p < .01, ∗∗∗p < .001 vs. Control.