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. 2022 Apr 12;22:100461. doi: 10.1016/j.bbih.2022.100461

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Effects of restraint stress on beta-adrenergic, inflammatory, and cell stress transcription factor activity.

Beta-adrenergic (CREB), inflammatory (NF-кB, AP-1, GR), and cell stress (Nrf2, HSF-1, HSF-2) transcription factor activity in bone marrow cells of mice randomized to Restraint (n = 10) or Propranolol (Prop) + Restraint (n = 6) vs. Control (n = 10) conditions, expressed as a Mean Log2 Ratio of transcription factor binding motif (TFBM) prevalence in the promoter regions of up-regulated versus down-regulated genes, averaged across nine parametric variations of promoter length and target TFBM match stringency. ∗p < .05, ∗∗p < .01, ∗∗∗p < .001 vs. null difference of zero. Brackets represent mean difference tests between Restraint and Prop + Restraint conditions.