Table 2.
GO and KEGG analysis for the DEGs.
| Category | Term | P-Value | Genes |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0022617∼extracellular matrix disassembly | 6.35E-10 | MMP12, MMP11, MMP13, LAMB3, MMP1, MMP3, SPP1, LAMC2, MMP10 |
| GOTERM_BP_DIRECT | GO:0030574∼collagen catabolic process | 2.01E-07 | MMP12, MMP11, MMP13, MMP1, MMP3, COL10A1, MMP10 |
| GOTERM_BP_DIRECT | GO:0008284∼positive regulation of cell proliferation | 1.48E-05 | CXCL10, TFAP2B, EDN3, ODC1, ID4, KIF14, LAMC2, PTHLH, SOX4, HOXC10, CDC25B |
| GOTERM_BP_DIRECT | GO:0030198∼extracellular matrix organization | 1.29E-04 | LAMB3, LOX, COL14A1, MFAP2, SPP1, COL10A1, LAMC2 |
| GOTERM_BP_DIRECT | GO:0001501∼skeletal system development | 2.16E-04 | HOXA10, SHOX2, COL10A1, PTHLH, SOX4, HOXC10 |
| GOTERM_BP_DIRECT | GO:0032467∼positive regulation of cytokinesis | 4.28E-04 | KIF14, CDC6, ECT2, CDC25B |
| GOTERM_BP_DIRECT | GO:0030199∼collagen fibril organization | 5.01E-04 | MMP11, LOX, COL14A1, SERPINH1 |
| GOTERM_BP_DIRECT | GO:0008285∼negative regulation of cell proliferation | 9.90E-04 | TFAP2B, CXCL8, IGFBP3, CXCL1, CDC6, PTHLH, SOX4, CDKN3 |
| GOTERM_BP_DIRECT | GO:0032461∼positive regulation of protein oligomerization | 0.001384 | MMP1, MMP3, BID |
| GOTERM_BP_DIRECT | GO:0006935∼chemotaxis | 0.001428 | CXCL10, CXCL8, PLAU, CCL20, CXCL1 |
| GOTERM_BP_DIRECT | GO:0070098∼chemokine-mediated signaling pathway | 0.002859 | CXCL10, CXCL8, CCL20, CXCL1 |
| GOTERM_BP_DIRECT | GO:0007275∼multicellular organism development | 0.004632 | HOXA10, MMP11, ANO1, HLF, EDN3, HMGA2, EMP1, HOXB7 |
| GOTERM_BP_DIRECT | GO:0008544∼epidermis development | 0.004749 | LAMB3, EMP1, LAMC2, PTHLH |
| GOTERM_BP_DIRECT | GO:0043065∼positive regulation of apoptotic process | 0.006892 | TOP2A, IGFBP3, HMGA2, ECT2, BID, SOX4 |
| GOTERM_BP_DIRECT | GO:0042769∼DNA damage response, detection of DNA damage | 0.009053 | HMGA2, DTL, SOX4 |
| GOTERM_BP_DIRECT | GO:0006508∼proteolysis | 0.014588 | MMP12, MMP11, MMP13, PLAU, MMP1, MMP3, MMP10 |
| GOTERM_BP_DIRECT | GO:0045944∼positive regulation of transcription from RNA polymerase II promoter | 0.015501 | TOP2A, HOXA10, CXCL10, TFAP2B, HLF, ATAD2, SHOX2, ID4, HMGA2, SOX4 |
| GOTERM_BP_DIRECT | GO:0097070∼ductus arteriosus closure | 0.019794 | TFAP2B, HPGD |
| GOTERM_BP_DIRECT | GO:0042035∼regulation of cytokine biosynthetic process | 0.027603 | IGF2BP3, IGF2BP2 |
| GOTERM_BP_DIRECT | GO:0060326∼cell chemotaxis | 0.02776 | CXCL10, CCL20, CXCL1 |
| GOTERM_BP_DIRECT | GO:0030593∼neutrophil chemotaxis | 0.028555 | CXCL8, EDN3, CCL20 |
| GOTERM_BP_DIRECT | GO:0043154∼negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 0.030994 | TFAP2B, LAMP3, IFI6 |
| GOTERM_BP_DIRECT | GO:0045444∼fat cell differentiation | 0.03437 | TFAP2B, ID4, HMGA2 |
| GOTERM_BP_DIRECT | GO:0032330∼regulation of chondrocyte differentiation | 0.03535 | SHOX2, PTHLH |
| GOTERM_BP_DIRECT | GO:0030071∼regulation of mitotic metaphase/anaphase transition | 0.03535 | UBE2C, CDC6 |
| GOTERM_BP_DIRECT | GO:0042127∼regulation of cell proliferation | 0.037708 | CXCL10, TFRC, PLAU, BID |
| GOTERM_BP_DIRECT | GO:2000406∼positive regulation of T cell migration | 0.039201 | CXCL10, CCL20 |
| GOTERM_BP_DIRECT | GO:0001558∼regulation of cell growth | 0.040602 | TFRC, IGFBP3, KIF14 |
| GOTERM_BP_DIRECT | GO:0009952∼anterior/posterior pattern specification | 0.040602 | HOXA10, HOXB7, HOXC10 |
| GOTERM_BP_DIRECT | GO:0043085∼positive regulation of catalytic activity | 0.041525 | IGFBP3, APOC1, CXCL1 |
| GOTERM_BP_DIRECT | GO:0031581∼hemidesmosome assembly | 0.046858 | LAMB3, LAMC2 |
| GOTERM_BP_DIRECT | GO:0021846∼cell proliferation in forebrain | 0.046858 | KIF14, HMGA2 |
| GOTERM_CC_DIRECT | GO:0005576∼extracellular region | 5.78E-09 | CXCL8, LAMB3, EDN3, TFRC, COL14A1, MMP1, CCL20, IGFBP3, MMP3, ISG15, CXCL1, LAMC2, PTHLH, MMP10, MMP12, MMP11, CXCL10, MMP13, LOX, PLAU, MFAP2, APOC1, SPP1, COL10A1 |
| GOTERM_CC_DIRECT | GO:0005578∼proteinaceous extracellular matrix | 6.07E-06 | MMP12, MMP11, MMP13, LOX, MMP1, COL14A1, MMP3, COL10A1, MMP10 |
| GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 2.21E-05 | CXCL8, EDN3, TFRC, COL14A1, CCL20, IGFBP3, MMP3, CXCL1, LAMC2, PTHLH, MMP10, CXCL10, MMP13, LOX, PLAU, SERPINH1, SPP1 |
| GOTERM_CC_DIRECT | GO:0005581∼collagen trimer | 2.22E-05 | MMP13, LOX, MMP1, COL14A1, SERPINH1, COL10A1 |
| GOTERM_CC_DIRECT | GO:0048471∼perinuclear region of cytoplasm | 0.007649 | TFRC, LAMP3, ODC1, SPP1, COBL, SORBS2, LAMC2, CDKN3 |
| GOTERM_CC_DIRECT | GO:0031012∼extracellular matrix | 0.023505 | MMP11, MMP13, MMP1, COL14A1, MMP10 |
| GOTERM_CC_DIRECT | GO:0005654∼nucleoplasm | 0.042373 | GINS1, TOP2A, HPGD, UBE2C, HSPB8, ATAD2, HMGA2, ISG15, CDC6, PTHLH, HOXC10, CDC25B, RBP1, MAGEA11, HOXB7, DTL, SOX4 |
| GOTERM_MF_DIRECT | GO:0004222∼metalloendopeptidase activity | 8.53E-05 | MMP12, MMP11, MMP13, MMP1, MMP3, MMP10 |
| GOTERM_MF_DIRECT | GO:0004252∼serine-type endopeptidase activity | 5.17E-04 | MMP12, MMP11, MMP13, PLAU, MMP1, MMP3, MMP10 |
| GOTERM_MF_DIRECT | GO:0008009∼chemokine activity | 9.66E-04 | CXCL10, CXCL8, CCL20, CXCL1 |
| GOTERM_MF_DIRECT | GO:0001077∼transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 0.014362 | HOXA10, TFAP2B, HLF, HMGA2, SOX4 |
| GOTERM_MF_DIRECT | GO:0004175∼endopeptidase activity | 0.019447 | MMP12, MMP1, MMP3 |
| GOTERM_MF_DIRECT | GO:0045182∼translation regulator activity | 0.023582 | IGF2BP3, IGF2BP2 |
| GOTERM_MF_DIRECT | GO:0005518∼collagen binding | 0.023691 | MMP13, COL14A1, SERPINH1 |
| GOTERM_MF_DIRECT | GO:0048027∼mRNA 5'-UTR binding | 0.035167 | IGF2BP3, IGF2BP2 |
| KEGG_PATHWAY | hsa05202: Transcriptional misregulation in cancer | 5.57E-06 | HOXA10, CXCL8, HPGD, PLAU, IGFBP3, MMP3, HMGA2, MLF1 |
| KEGG_PATHWAY | hsa05323: Rheumatoid arthritis | 0.0064 | CXCL8, MMP1, CCL20, MMP3 |
| KEGG_PATHWAY | hsa04668: TNF signaling pathway | 0.01095 | CXCL10, CCL20, MMP3, CXCL1 |
| KEGG_PATHWAY | hsa04622: RIG-I-like receptor signaling pathway | 0.036968 | CXCL10, CXCL8, ISG15 |
| KEGG_PATHWAY | hsa04062: Chemokine signaling pathway | 0.046265 | CXCL10, CXCL8, CCL20, CXCL1 |