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. 2022 Apr 25;64(2):229–236. doi: 10.1016/j.job.2022.04.004

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© 2022 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.

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Fig. 1 — TMPRSS2 expression in gingival lesions with periodontitis. (A) Violin plots of ACE2, TMPRSS2, and FURIN expression in gingival tissues from the GEO dataset, depicted in orange (healthy) and violet (periodontitis). ∗p < 0.05 vs. healthy samples. (B) IL-1β and TMPRSS2 expression in experimental periodontitis-induced gingivae. Ten mice (#1–#10) were subjected to experimental periodontitis induced by ligation of the maxillary right first molar. Total RNA was collected from the gingivae on the ligature (Ligature) and non-ligature (Control) sides and the levels of IL-1β and TMPRSS2 mRNAs were quantitated. The connected lines are individual lines. ∗p < 0.05. (C) Hematoxylin-eosin staining (HE; left panels) of a representative healthy gingiva (a) and periodontitis gingiva (b) as well as immunohistochemical staining (center and right panels) with anti-TMPRSS2 antibody using DAB. The dotted circles indicate the areas of inflammatory cell infiltration. The arrows indicate the basal layer of the gingival epithelium. Magnification: ×100 (left and center panels) and ×200 (right panels).