Fig. 3.

Screening for transcription factors with increased expression in tissues exhibiting periodontitis and that bind to the TMPRSS2 promoter. (A) Twenty-three nuclear-localized proteins with increased expression in tissues exhibiting periodontitis were selected using the GEO dataset and 50 proteins that bind to the TMPRSS2 promoter were selected using ChIP-Atlas. ESR1 was identified as the only transcription factor common to both datasets. (B) Violin plots of ESR1, ESR2, and AR expression in gingival tissues from the GEO dataset depicted in orange (healthy) and violet (periodontitis). (C) Correlation between the expression levels of TMPRSS2 and ESR1, ESR2, or AR. The regression line formula for TMPRSS2 and each gene is shown. The correlation coefficient (r) is also shown.