Table 1.
Gingival gene expression in healthy and periodontitis tissues.
| Gene symbol | Expression value average |
Ratio: Periodontitis/Healthyb | Adjusted p-valuec | |
|---|---|---|---|---|
| Healthy | Periodontitis | |||
| ACE2 | 4 | 3.7 | 0.8 | 3.5E−03 |
| TMPRSS2a | 8 | 8.7 | 1.7 | 1.5E−12 |
| FURIN | 7.6 | 7.9 | 1.2 | 6.9E−01 |
| IL-1βa | 8.3 | 9.3 | 2.1 | 1.6E−11 |
| IL-6a | 6.4 | 7.2 | 1.7 | 3.1E−03 |
| TNF-α | 5.3 | 5.4 | 1.1 | 1.0E−01 |
| HGFa | 4.2 | 4.4 | 1.2 | 5.3E−04 |
| SPP1 | 5.9 | 6.1 | 1.1 | 2.1E−01 |
| IFN-γ | 4.7 | 4.7 | 1.0 | 4.8E−02 |
| ESR1a | 4.9 | 5.4 | 1.5 | 1.6E−06 |
| ESR2 | 4.2 | 4.4 | 1.2 | 5.3E−02 |
| AR | 5.8 | 5.5 | 0.8 | 1.2E−01 |
a
Genes whose expression was statistically significantly upregulated in periodontitis tissues.
b
Since each gene expression value is expressed as a logarithm with a base of 2, the difference in the average expression values was used to calculate the ratio of gene expression between periodontitis and healthy samples.
c
The expression of each gene in gingival tissue samples was divided into two groups, periodontitis patients and healthy subjects. The Bonferroni test was utilized to obtain the p-values.