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. 2022 Apr 11;13:782982. doi: 10.3389/fimmu.2022.782982

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Copyright © 2022 Zhang, Tan, Zhang, Shi, Qi, Zou and Ci

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TME and transcriptomic characteristics of the three distinct pyroptosis patterns in the TCGA-MIBC cohort. (A) Differences in the expression of chemokines, receptors and MHC molecules between the three pyroptosis patterns in TCGA-MIBC. (B) Differences in various steps of the cancer immunity cycle between three pyroptosis patterns in TCGA-MIBC. (C) The abundance of each TME-infiltrating cell type in three pyroptosis patterns. The asterisks represent the statistical P value (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). (D) Heatmap representing the expression level of immune checkpoint genes in the three clusters. (E) Venn diagram showing pairwise DEGs for the three pyroptosis patterns.