REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse monoclonal anti-MBNL1	Wolfson Centre for Inherited Neuromuscular Disease	MB1a; RRID:AB_2618248
Rabbit monoclonal anti-GAPDH	Abcam	Cat# ab181602; RRID:AB_2630358
Rabbit polyclonal anti-RBFOX2	Sigma Aldrich	Cat# HPA006240; RRID:AB_1079750
Deposited data
Raw and analyzed data	This paper	SRA: PRJNA795461
Experimental models: Cell lines
Human: Non-disease fibroblasts	Laboratory of Laura Ranum	CNTRL-A
Human: Non-disease fibroblasts	Laboratory of Laura Ranum	CNTRL-B
Human: DM1 fibroblasts	Laboratory of Laura Ranum	DM1-A
Human: DM1 fibroblasts	Laboratory of Laura Ranum	DM1-B
Human: DM2 fibroblasts	Laboratory of Laura Ranum	DM2-A
Human: DM2 fibroblasts	Laboratory of Laura Ranum	DM2-B
Human: DM2 fibroblasts	Laboratory of Laura Ranum	DM2-C
Human: DM2 fibroblasts	Laboratory of Laura Ranum	DM2-D
Oligonucleotides
DsiRNA targeting sequence: MBNL1	IDT	hs.Ri.MBNL1.13.1
Negative Scramble DsiRNA control	IDT	Cat# 51-01-19-09
FISH CTG repeat probe: Cy3-CAGCAGCAGCAGCAGCAGCAGCAG	IDT	N/A
FISH CCTG repeat probe: Cy3-CAGGCAGGCAGGCAGGCAGGCAGG	IDT	N/A
All qPCR primer sequences listed in Table 1 in Method details	IDT	N/A
All splicing primers sequences listed in Table 2 in Method details	IDT	N/A
Software and algorithms
Prism 7	GraphPad	https://www.graphpad.com/scientific-software/prism/
STAR	https://doi.org/10.1093/bioinformatics/bts635	version 2.5.1b
rMATS	https://doi.org/10.1073/pnas.1419161111	version 3.2.5
GeneOntology Tools	https://doi.org/10.1038/75556 and https://doi.org/10.1093/nar/gkaa1113	Various