Table 3.

Subgroup analysis of overall survival for serum AFP trajectories stratified by clinical features.

	Event/N	high-rising vs. low-stable		sharp-falling vs. low-stable
		HR (95%CI)	P-value*	HR (95%CI)	P-value*
Gender			0.014	0.46(0.29,0.72)	0.23
male	281/610	4.75 (3.65, 6.18)		0.76(0.36,1.61)
female	80/271	10.60 (6.29, 17.86)
Age (years)			0.046		0.097
<55	179/454	6.78 (4.79, 9.59)		0.70(0.43,1.15)
≥55	182/427	4.67 (3.39, 6.42)		0.35(0.19, 0.64)
Child-Pugh class			0.033		0.52
A	307/738	5.58 (4.33, 7.17)		0.52(0.35,0.79)
B	34/82	23.01 (8.07, 65.63)		0.65(0.19,2.28)
Intrahepatic lesions number			0.12		0.26
<3	134/367	7.73 (5.22, 11.44)		0.38(0.20, 0.73)
≥3	227/514	4.67 (3.49, 6.25)		0.62(0.39, 0.99)
Diameter of main tumor(cm)			0.69		0.77
<5	101/331	6.21(3.75, 10.26)		0.51(0.25,1.06)
≥5	260/550	4.68 (3.57, 6.12)		0.47(0.30,0.74)
Derivation cohort			0.27		0.88
No	180/526	6.37 (4.57, 8.87)		0.50(0.30, 0.86)
Yes	181/355	4.81(3.47, 6.67)		0.53(0.31,0.92)

^⁎P value for interaction. HR(95%CI) = hazard ratio(95% confidence intervals). AFP=α-fetoprotein.