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. 2022 Mar 23;298(5):101850. doi: 10.1016/j.jbc.2022.101850

Figure 7.

Figure 7

Survival rates in Gsdme−/−mice infected with EV71.A and B, 3-day-old C57BL/6 WT and Gsdme−/− mice were injected via the intraperitoneal route. The same volumes of DMEM were used as the control. Body weight (A) and survival rate (B) were monitored. All data are mean values ± SD. ∗p < 0.05, ∗∗p < 0.01. C–E, 3-day-old WT and Gsdme−/− mice were infected with EV71 by intraperitoneal injection. At 3 DPI, peripheral blood samples were harvested and cytokine concentrations in the blood were analyzed by BDTM Cytometric Bead Array (CBA) Mouse Inflammatory Cytokines Kit (BD Biosciences). p Values are indicated. F–H, EV71 RNA levels in muscles, intestines, and brains were monitored in WT and Gsdme−/− mice. One dot point indicates one animal. DMEM, Dulbecco’s modified Eagle’s medium; DPI, days postinfection; EV71, enterovirus 71; Gsdme, gasdermin E.