Figure 2.

Thrombus area, aortic and peritoneal macrophage tissue factor levels in chronic APS mouse model. Both thrombus area (A) and aortic TF (B) levels decreased significantly in β₂GPI-immunized mice treated with non-PEG-DI, 20kDa PEG-DI and 40kDa PEG-DI compared to β₂GPI-immunized positive control mice. The abrogated levels of thrombus development and aortic TF were similar to that seen in negative control mice. While there was a trend of decreased peritoneal macrophage TF (C) levels in all domain I treated mice, the noted reductions were not statistically significant. (*p<0.01, **p<0.001).