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. 2022 Apr 11;13:854749. doi: 10.3389/fimmu.2022.854749

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Copyright © 2022 Gentile, Miano, Terranova, Giardino, Faraci, Pierri, Drago, Verzola, Ghiggeri, Verrina, Angeletti, Cafferata, Grossi, Ceccherini, Caridi, Lugani, Nescis, Fiaccadori, Lanino, Fenoglio and La Porta

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(A) Mild thickening of the capillary wall and glomerular basement membrane. Bowman capsule enlargement and reduplication (periodic Schiff-methenamine silver, original magnification: ×400). (B) Interstitial and peri-tubular IgG4 deposits. Mild tubular atrophy and interstitial fibrosis. Moderate focal and periglomerular lymphoplasmacytic infiltrate (PAS + IgG4 IHC, original magnification: ×100). (C) Glomerular sub-epithelial deposits with granular pattern (immunofluorescence for anti-PLA2R antibodies, original magnification: ×400). (D) Absence for THSD7A glomerular expression (IHC original magnification: ×200).