Table 1.
Top 20 Potential Targets Associated with CI in Ketamine Treatment
| Gene Symbol | Protein Names | Degree | Betweenness |
|---|---|---|---|
| APP | Amyloid-beta precursor protein | 71 | 111 |
| SRC | Proto-oncogene tyrosine-protein kinase Src | 61 | 350 |
| HSP90AA1 | Heat shock protein HSP 90-alpha | 56 | 240 |
| GRB2 | Growth factor receptor-bound protein 2 | 54 | 98 |
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 45 | 101 |
| DLG4 | Disks large homolog 4 | 45 | 92 |
| ADRB2 | Beta-2 adrenergic receptor | 44 | 52 |
| FYN | Tyrosine-protein kinase Fyn | 43 | 112 |
| PARK2 | E3 ubiquitin-protein ligase parkin | 39 | 134 |
| SNCA | α-Synuclein | 38 | 88 |
| CTNNB1 | Catenin beta-1 | 37 | 51 |
| AKT1 | RAC-alpha serine/threonine-protein kinase | 36 | 67 |
| CBL | E3 ubiquitin-protein ligase CBL | 34 | 67 |
| ACTB | Actin, cytoplasmic 1 | 34 | 76 |
| ARRB1 | Beta-arrestin-1 | 34 | 49 |
| CAV1 | Caveolin-1 | 33 | 85 |
| PRKCA | Protein kinase C alpha type | 33 | 72 |
| HSPA5 | Endoplasmic reticulum chaperone BiP | 32 | 60 |
| GRIN2A | Glutamate receptor ionotropic, NMDA 2A | 32 | 70 |
| PLCG1 | 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 31 | 60 |