Table 3.
Ketamine’s Top 10 Targets Based on Docking Scores
| Gene Symbol | Protein Names | Docking Score (kcal/mol) |
|---|---|---|
| SNCA | α-Synuclein | −9.9 |
| NOS1 | Nitric oxide synthase | −8.9 |
| CHRM1 | Muscarinic acetylcholine receptor M1 | −7.8 |
| SRC | Proto-oncogene tyrosine-protein kinase Src | −7.7 |
| HSPA5 | Endoplasmic reticulum chaperone BiP | −7.6 |
| HTR2A | 5-Hydroxytryptamine receptor 2A | −7.4 |
| FYN | Tyrosine-protein kinase Fyn | −6.9 |
| HSP90AA1 | Heat shock protein HSP 90-alpha | −6.8 |
| ADRB2 | Beta-2 adrenergic receptor | −6.8 |
| ARRB1 | Beta-arrestin-1 | −6.7 |