Table 2.
Secondary outcomes
| Outcome | Description/score | Timepoint |
| Rehabilitation | Type, frequency, modalities (ambulatory/hospital), number of sessions performed/number of scheduled sessions after ICU discharge | 6, 12 months |
| Respiratory status | Dyspnoea (mMRC)26 | 6, 12 months |
| Oxygen saturation by pulse oximetry (SpO2) at rest and in room air | 6, 12 months | |
| 6MWT performed according to the ERS/ATS guidelines27 | 6 months 12 months for patients with desaturation during exercise, or walked distance <90% of the theoretical value on 6MWT at 6 months |
|
| Functional respiratory status: PFT including spirometry (FEV1, FVC, FEV1/FVC), plethysmography (TLC, RV, FRC, VC, RV/TLC) and diffusion capacity of the lung (DLCO, DLCO/VA) according to ERS/ATS guidelines28 29 | 6 months 12 months for patients with at least one of the following: FVC <80% of the theoretical value, FEV1 <80% of the theoretical value, DLCO <80% at 6 months |
|
| Lung parenchyma | Thin-slice non-enhanced chest CT | 6 months 12 months for patients with pulmonary involvement (fibrosis-like lesions, reticular and/or residual ground glass opacities, mosaic pattern) on chest CT at 6 months |
| Olfaction and taste | Questionnaire and quantification of alteration using visual analogue scale | Inclusion, 6 months |
| Neuromuscular status | Muscular autonomy (ADL30, 6MWT) | 6, 12 months |
| Cognitive status | MoCA31 | 6, 12 months |
| Psychological status | Post-traumatic stress disorder (PTSD) (IES-R)32
Anxiety and/or depression (HADS)33 |
6, 12 months |
| Quality of life | SF-3634
VSRQ35 |
6, 12 months |
| Vital status | Medical files or contact with patient or his/her relatives | 12 months |
| Nutritional state | Weight, food intake | Inclusion and 6 months |
| Qualitative study: barriers and facilitators to rehabilitation, as perceived by the patients |
Semistructured interviews after return to home | Between 8 and 10 months |
ADL, activities of daily living; DLCO, diffusion capacity of the lung for carbon monoxide; ERS/ATS, European Respiratory Society/American Thoracic Society; FEV1, forced expiratory volume in 1 s; FRC, functional residual capacity; FVC, forced vital capacity; HADS, Hospital Anxiety and Depression Scale; ICU, intensive care unit; IES-R, Impact of Event Scale Revised; mMRC, modified Medical Research Council; MoCA, Montreal Cognitive Assessment; 6MWT, 6 min walk test; PFT, pulmonary function test; RV, residual volume; SF-36, Short Form Health Survey modified 36; SpO2, peripheral capillary oxygen saturation; TLC, total lung capacity; VA, alveolar volume; VC, vital capacity; VSRQ, Visual Simplified Respiratory Questionnaire.