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. 2022 Apr 22;10(4):e002838. doi: 10.1136/jitc-2021-002838

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Signaling by heterodimeric type I interferon (IFN) receptor and changes of conformation on activation of the IFN receptor by its ligands. JAK1 binds to boxes 1 and 2 motifs of the cytosolic domain of ifnar2 respectively via the FERM and SH2 domains. Tyk2 binds to the cytosolic domain of IFNAR1. EC, extracellular; IC, intracellular; IFN, interferon; IL, intereukin; JAK, Janus kinase.