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. 2022 Apr 11;12:813953. doi: 10.3389/fcimb.2022.813953

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Copyright © 2022 Zhou, Ji, Yao, Guo, Zhang, Wang and Du

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginsenoside Rd led the alleviation of bone resorption in vivo. (A) The sketch of the animal experiment. (B) Reconstructed images of the alveolar bones of mice were obtained by micro-CT scanning. The CEJ–ABC distance was indicated by the red lines and was measured according to the scale. (C) Bone histomorphometry indexes (BV/TV, BS/TV, and Tb.N) in the ROI. The results are shown as mean ± SD (n = 3). ^* p < 0.05 versus the normal control; ^# p < 0.05 versus the periodontitis group. (D) HE staining of the periodontal tissues of mice.