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. 2022 Apr 25;12:6708. doi: 10.1038/s41598-022-10187-y

Figure 6.

Figure 6

Effect of derivatives (2, 3) and vildagliptin, saxagliptin on the protein level of GLP-1 and DPP4 in prefrontal cortex of diabetic mice. GLP-1 (A) and DPP4 (B) protein levels in prefrontal cortex tissues of mice after 14-days treatment with DPP41s or new adamantane derivatives (2, 3). Bars in figure illustrates experimental groups—CTL non-diabetic mice, DM diabetic mice, DM-Vil vildagliptin-treated mice [20 mg/kg, po], DM-Sax saxagliptin-treated mice [10 mg/kg, po], DM-compound 2 compound 2-treated mice [50 mg/kg, po], DM-compound 3 compound 3-treated mice [50 mg/kg, po], respectively. Data is presented as mean ± SD (n = 8). One-way ANOVA, followed by Tukey's post hoc test was used. *p < 0.05; **p < 0.01 as compared with healthy control group; ##p < 0.01, ###p < 0.001 compared with diabetic mice group.