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. 2022 Apr 25;12:6708. doi: 10.1038/s41598-022-10187-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-inflammatory effects of novel adamantane derivatives (2,3), and drugs- vildagliptin and saxagliptin in brain of diabetic mice. Comparison of IL-1β (A), IL-6 (B), and tumor necrosis factor-α (TNFα) (C) among the experimental groups. Bars in figure illustrate experimental groups—CTL non-diabetic mice, DM diabetic mice, DM-Vil vildagliptintreated mice [20 mg/kg, po], DM-Sax saxagliptin-treated mice [10 mg/kg, po], DM-compound 2 compound 2-treated mice [50 mg/kg, po], DM-compound 3 compound 3-treated mice [50 mg/kg, po], respectively. Data is presented as mean ± SD (n = 8). One-way ANOVA, followed by Tukey's post hoc test was used. p < 0.05, **p < 0.01 in comparison with control group; ^#p < 0.05 and ^##p < 0.01, ^###p < 0.001 in comparison with diabetes group.