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. 2022 Apr 11;13:866352. doi: 10.3389/fneur.2022.866352

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Copyright © 2022 Kajimoto, Kameda, Kambara, Kuroda, Tsuji, Nikaido, Saura and Wanibuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vicious (A) and virtuous (B) circles between frontal lobe function and activity of life. (A) Deterioration of the patient's frontal lobe function reduces motivation, such as spontaneity, and leads the patient to a more inactive life. As a result, cognitive and physical functions decline due to disuse, leading to a vicious cycle of further decline in frontal lobe function. (B) Maintaining and improving frontal lobe function maintains and improves motivation, including spontaneity, and restores an active lifestyle. As a result, cognitive and physical functions enter a virtuous cycle of improvement.