Table 1.
Clinical characteristics and postoperative course of 12 patients with prodromal phase iNPH.
| No. | Age | Sex | OP | Fall count | IGD | TUG (s) | Diagnostic trigger | High performance activity (duration) | MMSE/FAB preOP | MMSE/FAB after 1 year | MMSE/FAB after 4/3 years | Antidepressant preOP/postOP | Antidementia drug preOP/postOP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 65 | M | VP | 0 | − | 10.8 | AVIM Following | Bamboo flute (4y-) | 30/16 | 30/16 | 29/15 | Aripiprazole/none | None/none |
| 2 | 63 | M | LP | 0 | − | 11.3 | MRI for dementia Dx | none | 28/13 | 28/16 | 25/11 | Aripiprazole/none | None/none |
| 3 | 74 | M | VP | 4 | + | 8.0 | CT at fall | President(4y-), Golf(2y) | 28/16 | 26/16 | 28/14 | None/none | None/none |
| 4 | 72 | M | VP | 1 | + | 9.9 | AVIM Following | President(2y), Golf(4y-) | 27/16 | 27/18 | 24/17 | None/none | None/Rivastigmine |
| 5 | 86 | M | VP | 2 | + | 11.6 | MRI for dementia Dx | Karaoke(4y-) | 29/14 | 28/14 | 24/13 | None/none | None/none |
| 6 | 77 | M | LP | 1 | − | 11.2 | MRI for dementia Dx | Pilgrimage(1y) | 27/12 | 22/11 | 21/12 | None/none | None/donepezil |
| 7 | 71 | M | LP | 1 | + | 8.4 | MRI for dementia Dx | Gym(4y-) | 26/11 | 29/13 | 27/NA | Maprotiline/none | None/none |
| 8 | 77 | M | LP | 1 | + | 10.7 | MRI for PD Dx | Flower Photography Blog(4y-) | 26/14 | 28/17 | 27/15 | None/none | None/none |
| 9 | 68 | M | LP | 1 | + | 13.2 | CT at fall | none | 25/13 | 27/16 | 29/11 | None/none | None/none |
| 10 | 75 | M | LP | 2 | + | 11.5 | CT at fall | Golf(4y-), Travel(4y-) | 26/13 | 28/17 | 30/NA | None/none | None/none |
| 11 | 74 | F | LP | 1 | + | 10.4 | AVIM Following | Japanese Harp Master(4y-) | 26/14 | 28/14 | 26/14 | None/none | Donepezil/none |
| 12 | 78 | F | LP | 0 | − | 11.9 | MRI for dementia Dx | Chorus(3y), Gym(3y) | 28/17 | 29/14 | 26/NA | None/none | none/none |
Fall count and IGD represent the number of falls and the presence of intermittent gait disturbance (IGD) before surgery. The 4y- in duration means more than 4 years.
INPHGS, iNPH grading scale; IGD, intermittent gait disturbance; MMSE, mini-mental state examination; FAB, frontal assessment battery; LP, lumbo-peritoneal; VP, ventriculo-peritoneal; AVIM, asymptomatic ventriculomegaly with features of iNPH on MRI; PD, Parkinson's disease; Dx, diagnosis.