Figure 4.

Navigation using clinically relevant magnetic field gradient strengths. a) Distance moved versus magnetic field gradient strength for a 3 mm thermoseed through 0.125% agar, using a Connectom system designed for human imaging. Distance moved increased with increasing gradient strength. Data analyzed using simple linear regression, n = 6 measurements for each gradient strength, p < 0.0001. b,c) A 3 mm thermoseed was navigated through ex vivo porcine brain tissue with a clinical gradient strength of 300 mT m⁻¹ (maximum limit of the Connectom system) and duty cycle of 100%. The thermoseed was navigated 45 and 53 mm in samples B and C, respectively. d) A 3 mm thermoseed was navigated 8 mm through ex vivo brain tissue, with a gradient strength of 400 mT m⁻¹ and a clinical duty cycle of 15% (maximum limit of the Connectom system). Movement was most efficient when using a clinically relevant gradient strength of 300 mT m⁻¹ applied continuously. Each circle represents an individual movement.