Figure 5.

Heating the thermoseed in vitro and in vivo. a) Position of thermoablative device around a rodent's head. Insert: Thermoablative device placed inside the bore of the MRI scanner. b) Change in temperature on the surface of thermoseeds of different sizes as they were heated by the thermoablative device in air. Data shown as mean ± S.D., n = 3. c) Photos of TTC stained 3D cell cultures following 0, 1, and 5 min of heating with a 2 mm thermoseed show a clear perimeter of cell death (red = alive cells, clear = dead cells). Scale bar = 5 mm. d) Cross‐sectional area of cell death for different heating durations. A longer duration of heating causes a larger area of cell death. n ≥ 2 measurements for each heating duration. e) Rat brain slices stained with TTC solution following 1 min of heating with a 2 mm thermoseed show a well‐defined area of cell death (blue ROI). Scale bar = 5 mm.