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. 2022 Feb 24;9(12):2105672. doi: 10.1002/advs.202105672

Figure 1.

Figure 1

Depression‐related genes that play roles in breast cancer. a) The expression of 28 depression‐related genes after silenced by siRNA in LM2 cells. b,c) The proliferation and migration ability of breast cancer cells with specific gene silenced. The pink graph represents the tumor suppressive genes, while the blue graph represents the tumor promoting genes. d) The representative image of migration of HTR1A, PTRRR, CHST11, MTHFR, and ADCY9. e) The recurrence free survival (RFS) probability and hazard ratio (HR) of HTR1A, PTRRR, CHST11, MTHFR, and ADCY9 in Kaplan–Meier plotter database. f,g) The Kaplan–Meier plotter database showed the OS and RFS with the expression of HTR1A in breast cancer patients.h,i) Real‐time PCR and western blotting showed the mRNA and protein expression of HTR1A in breast cancer cell lines, respectively. j) The expression of HTR1A in TNBC tissues compared with their paracancerous tissues. k) The Oncomine database showed the expression of HTR1A in normal and tumor tissue(left), primary and metastatic breast cancer (middle), and non metastasis and metastasis cancer (right ). l) The bc‐GenExMiner v4.8 database indicated the expression of HTR1A in TNBC and non‐TNBC tissues.