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. 2022 Feb 24;9(12):2105672. doi: 10.1002/advs.202105672

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© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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HTR1A inhibits the TGF‐β/TβRII/MEK/ERK/c‐Myc noncanonical pathway. a) HTR1A significantly inhibited the phosphorylation levels of MEK and ERK as well as the expression level of c‐Myc. b) LY2109761 could rescue the noncanonical MEK/ERK/c‐Myc signaling pathway in HTR1A stable knockdown cell lines. c) The effect of 10058‐F4, GDC‐0994, and Binimetinib treatment on the activation level of MEK/ERK/c‐Myc signaling pathway in HTR1A knockdown cell lines. d) The effect of WAY100635, 5‐HT, and 8‐OHDPAT on TGF‐β canonical and noncanonical pathways in HTR1A stable cell lines.