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. 2022 Apr 11;9:868640. doi: 10.3389/fnut.2022.868640

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Copyright © 2022 Okabe, Yaku, Uchida, Fukamizu, Sato, Sakurai, Tobe and Nakagawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical trial diagram. Clinical trial diagram based on the CONSORT. A total of 42 potential participants were screened, and 30 eligible participants were selected and randomized into nicotinamide mononucleotide (NMN) and placebo groups in a 1:1 ratio. One participant in placebo group was dropped out from the study at 8-week, and 29 participants completed the study.