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. 2022 Apr 11;9:868640. doi: 10.3389/fnut.2022.868640

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Copyright © 2022 Okabe, Yaku, Uchida, Fukamizu, Sato, Sakurai, Tobe and Nakagawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No adverse event was observed in laboratory data for safety evaluation of NMN oral administration. Hematological (A) and biochemical (B) blood tests were performed every 4 weeks. Orange represents placebo group (n = 15 at 0, 4, 8 weeks, n = 14 at 12, 16 weeks) and blue represents NMN group (n = 15). Data are represented as mean ± SD. WBC, white blood cells; Hb, hemoglobin; Ht, hematocrit; Plt, platelets; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GT, gamma-glutamyl transferase; ALP, alkaline phosphatase; UN, urine nitrogen; Cre, serum creatinine; TP, total protein; Alb, albumin; Na, serum sodium; K, serum potassium; Cl, serum chloride; Ca, serum calcium; Mg, serum magnesium; Fe, serum iron; IP, inorganic phosphorus; LD, lactate dehydrogenase. Asterisk means statistical significance: p-value < 0.05.