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. 2022 Apr 11;9:868640. doi: 10.3389/fnut.2022.868640

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Copyright © 2022 Okabe, Yaku, Uchida, Fukamizu, Sato, Sakurai, Tobe and Nakagawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of NAD⁺ and NAMN in blood were increased by oral administration of NMN. NAD metabolome in blood was measured every 4 weeks. NAD metabolome in each time point was showed in box plots. In the box plots, the median is indicated by the line within the boxes. The lower and upper boundaries of the boxes indicated 25th and 75th percentiles. The upper and lower lines above and below the boxes represent the whiskers. Orange boxes represent placebo group (n = 15 at 0, 4, 8 weeks, n = 14 at 12, 16 weeks) and blue boxes represents NMN group (n = 15). Levels of MNAM were calculated by integrating peak area of each chromatogram (MS counts). Three asterisks mean statistical significance: p-value < 0.001.