Table 3.

Performance of a single lncRNA for PTC diagnosis and LN metastasis

Event	Lnc-LRRK2-1:1	FAM230B	Lnc-MPEG1-1:1	Lnc-ABCA12-5:2	Lnc-RXRG-1:10
Predicting PTC
TCGA cohort
AUC (95% CI)	0.94 (0.92–0.96)	0.83 (0.79–0.87)	0.84 (0.81–0.88)	0.89 (0.86–0.92)	0.90 (0.88–0.93)
p	5.05 × 10−28	1.07 × 10−16	2.11 × 10−17	1.57 × 10−22	7.25 × 10−24
SYSUCC cohort
AUC (95% CI)	0.80 (0.72–0.87)	0.89 (0.84–0.95)	0.84 (0.77–0.90)	0.76 (0.68–0.84)	0.90 (0.84–0.95)
p	3.32 × 10−10	60.2 × 10−17	7.65 × 10−13	2.22 × 10−8	3.64 × 10−17
Predicting LN metastasis
TCGA cohort
AUC (95% CI)	0.55 (0.50–0.60)	0.60 (0.55–0.65)	0.70 (0.66–0.75)	0.71 (0.67–0.76)	0.66 (0.61–0.71)
p	0.07	2.00 × 10−4	9.56 × 10−14	7.60 × 10−15	6.01 × 10−9
SYSUCC cohort
AUC (95% CI)	0.56 (0.42–0.70)	0.68 (0.56–0.80)	0.70 (0.57–0.84)	0.65 (0.52–0.78)	0.60 (0.46–0.73)
p	0.38	7.64 × 10−3	2.52 × 10−3	0.02	0.15