| Methods |
Parallel, study duration eight weeks, follow‐up at 10 weeks |
| Participants |
389 participants with treated and controlled hypertension, 70 per cent men, mean age 54 years, primary care, Canada |
| Interventions |
SIMPLIFICATION OF DOSING REGMENS: Metoprolol 200mg once daily versus metroprolol 100mg twice daily |
| Outcomes |
PILL COUNT: 96 per cent took more than 80 per cent of medication in the intervention group (once‐daily regimen) compared to 90 per cent in the control group (p equals 0.059). 93 per cent took more than 90 per cent of medication in the intervention group compared to 82 per cent in the control group (p equals 0.009). 1 mmHg net reduction in systolic blood pressure and no net reduction for diastolic blood pressure (not statistically significant, no exact p‐value reported) |
| Notes |
Detailed reasons for loss to follow‐up reported. Randomisation procedure and blinding to outcome assessment unclear. |
