Table 2.

DMDs effect on severe COVID-19 risk and vaccine response.

DMD	Severe COVID-19 Risk OR (95% IC)	Effects on Vaccine Response
Interferons	0.42 (0.18–0.99)	n.s. §
Glatiramer acetate	n.s. §	n.s. §
Teriflunomide	Significant #	n.s. §
Dimethyl fumarate	n.s. §	n.s. §
S1P modulators	n.s. §	Reduced humoral and cellular response
Cladribine	n.s. §	n.s. §
Anti-CD20	2.05 [1.39–3.02]	Reduced humoral response
Natalizumab	n.s. §	n.s. §
Alemtuzumab	n.s. §	n.s. §

^§ n.s., not significant. ^# negative correlation between lethality and the percentage of patients under treatment with teriflunomide (p-value 0.035). References: [2,4,5,6,7,8,13,14,15,16,25].