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. 2021 Jul 1;11(38):23192–23206. doi: 10.1039/d1ra00208b

Screening the reaction conditionsa.

graphic file with name d1ra00208b-u3.jpg
Entry Solvent Catalyst (mol%) Temp. (°C) TBHP (mmol) Yieldb (%)
1 Water 1 40 2 40
2 EtOH 1 40 2 75
3 CH3CN 1 40 2 60
4 Solvent free 1 40 2 92
5 Solvent free 1 RT 2 50
6 Solvent free 1 40 2 92
7 Solvent free 1 60 2 65
8 Solvent free 40 2 25
9 Solvent free 0.5 40 2 65
10 Solvent free 1 40 2 92
11 Solvent free 1.5 40 2 92
12 Solvent free 2 40 2 94
13 Solvent free 1 40 0.5 60
14 Solvent free 1 40 1 92
15 Solvent free 1 40 1.5 85
16 Solvent free 1 40 2 70
a

Reaction conditions: benzyl alcohol (1 mmol), 30 min.

b

Yields of product isolated.