Screening the reaction conditionsa.
Entry | Solvent | Catalyst (mol%) | Temp. (°C) | TBHP (mmol) | Yieldb (%) |
---|---|---|---|---|---|
1 | Water | 1 | 40 | 2 | 40 |
2 | EtOH | 1 | 40 | 2 | 75 |
3 | CH3CN | 1 | 40 | 2 | 60 |
4 | Solvent free | 1 | 40 | 2 | 92 |
5 | Solvent free | 1 | RT | 2 | 50 |
6 | Solvent free | 1 | 40 | 2 | 92 |
7 | Solvent free | 1 | 60 | 2 | 65 |
8 | Solvent free | — | 40 | 2 | 25 |
9 | Solvent free | 0.5 | 40 | 2 | 65 |
10 | Solvent free | 1 | 40 | 2 | 92 |
11 | Solvent free | 1.5 | 40 | 2 | 92 |
12 | Solvent free | 2 | 40 | 2 | 94 |
13 | Solvent free | 1 | 40 | 0.5 | 60 |
14 | Solvent free | 1 | 40 | 1 | 92 |
15 | Solvent free | 1 | 40 | 1.5 | 85 |
16 | Solvent free | 1 | 40 | 2 | 70 |
Reaction conditions: benzyl alcohol (1 mmol), 30 min.
Yields of product isolated.