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. 2022 Apr 11;13:792798. doi: 10.3389/fphar.2022.792798

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Copyright © 2022 Numata and Takimoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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cGMP/PKG signaling in cardiomyocyte cGMP-PKG signaling is enhanced by two pathways. The former is NO-sGC-cGMP pathway and the latter is NP-NPR-pGC pathway. cGMP derived from NO-sGC pathway takes hydrolyzation by PDE5, and cGMP from NP-pGC pathway by PDE9 and PDE5 (especially in stressed conditions). cGMP/PKG signaling exerts protective effects in cardiomyocyte by phosphorylate various proteins like RGS2/4, Troponin I, TSC2, cMyBP-C, or Titin.