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. 2021 Jul 2;11(37):22859–22920. doi: 10.1039/d1ra03513d

Niobium oxide-mediated catalysis49.

graphic file with name d1ra03513d-u113.jpg
Entry R1 R2 R3 Time (h) Conversiona (%) Yield (%)
1 Me Et H2C Created by potrace 1.16, written by Peter Selinger 2001-2019 CHCH2 6 65 52
2 Me Me H2C Created by potrace 1.16, written by Peter Selinger 2001-2019 CHCH2 6.5 70 58
3 graphic file with name d1ra03513d-u114.jpg H2C Created by potrace 1.16, written by Peter Selinger 2001-2019 CHCH2 8 85 57
4 Me Et graphic file with name d1ra03513d-u115.jpg 5 75 58
5 Me Me graphic file with name d1ra03513d-u116.jpg 5.5 80 76
6 graphic file with name d1ra03513d-u117.jpg graphic file with name d1ra03513d-u118.jpg 8 70 63
7 Me Me n Bu 5.5–7 100 (100, 100)b 98 (93, 87)b
8 Me Me t Bu 8 93 60
9 Me Me iPr 8 81 63
10 Me Me Bn 12 50 33
11 graphic file with name d1ra03513d-u119.jpg (−)-Menthyl 8 65c 61c
a

Conversion determined by GC of the crude reaction mixture.

b

Catalyst was recovered and reused three times without appreciable activity loss.

c

Diester product.