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. 2022 Apr 11;9:845271. doi: 10.3389/fmed.2022.845271

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Copyright © 2022 He, Zhang, He, Huang, Man, Wang, Lang and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subgroups of colon cancer related by necroptosis-related regulators. (A) Consensus clustering of colon patients for k = 2 in the meta-cohort (GSE39582, GSE17536 and TCGA-CORD). (B) Kaplan-Meier curves (Log-rank test, P = 0.008) for overall survival (OS) of two necroptosis-related molecular subtypes. (C) GSVA enrichment analysis showed the activation status of biological pathways in two necroptosis-related molecular subtypes. Red: activation of biological pathways, blue: inhibition of biological pathways. (D) ssGSEA analysis showed the difference in the abundance of TME-infiltrated cells between the two subtypes (*P < 0.05; **P < 0.01; ***P < 0.001; ns, not statistically significant).