TABLE 2.

MICs for 18 strains of N. gonorrhoeae with altered quinolone resistance with details of phenotype, GyrA and ParC changes, and geographic source

Strain no.	Yr	MICa (μg/ml) of:				Typeb (A/S class)	Sequence change(s)c		Geographic sourced
		CIP	GRX	MXF	TVA		GyrA	ParC
1	1993	0.12	0.12	0.12	0.03	Pro/A6	D95N		O
2	1997	0.12	0.12	0.25	0.03	Nr/B4	D95G		U
3	1991	0.12	0.25	0.25	0.12	Nr/A4	D95N		P
4	1998	0.25	0.5	0.5	0.06	Nr/B3	D95N		T
5	1991	0.5	0.5	0.5	0.12	Pro/B8	S91F		T
6	1992	0.5	0.5	0.5	0.25	Nr/B3	S91Y		P
7	1998	1	1	0.5	0.12	Nr/B4	S91F		T
8	1996	1	0.5	0.5	0.5	Pro/B2	S91Y	E91Q	C
9	1997	2	1	2	0.12	Nr/B6	S91F, D95G	S88P	U
10	1997	2	2	2	1	Nr/A6	S91F, D95G	D86N	P
11	1997	4	2	4	0.12	Nr/B3	S91F, D95G	S88P	A
12	1996	4	4	2	2	Pro/A6	S91F, D95G	D86N	U
13	1998	8	4	2	1	Pro/A6	S91F, D95G	S87R	C
14	1998	8	8	4	4	Nr/A6	S91F, D95N	E91K	C
15	1995	8	16	4	4	Nr/B7	S91F, D95G	E91K, S87N	U
16	1995	16	32	8	8	ProArg/B3	S91F, D95G	E91K, S87N	B
17	1995	16	32	8	8	Nr/B7	S91F, D95G	E91K, S87N	U
18	1995	16	16	8	2	Arg/B4	S91F, D95N	S87R	A

^aCIP, ciprofloxacin; GRX, grepafloxacin; MXF, moxifloxacin; TVA, trovafloxacin. 

^bNr, nonrequirer; Pro, proline requirer; Arg, arginine requirer; A/S, auxotype/serotype. 

^cD, aspartate; N, asparagine; G, glycine; S, serine; F, phenylalanine; Y, tyrosine; E, glutamine; Q, glutamate; P, proline; R, arginine; K; lysine. 

^dO, overseas, unknown; U, unknown; P, Philippines; T, Thailand; C, China; A, Australia; B, Bali, Indonesia.