Table 2.
Molecular determinants of 1918 virus transmission in ferrets.
| Gene segments from 1918 virusa |
Transmissionb | Conclusion |
|---|---|---|
| All | 3/3 | Efficient transmission of fully reconstructed 1918 virus |
| None | 0/3 | No transmission of avian H1N1 virus |
| HA | 0/3 | 1918 surface glycoproteins not sufficient for transmission |
| HA, NA | 0/3 | |
| HA, NA, pol complex (PA, PB1, PB2) | 3/3 | Role for internals |
| HA, NA, PA | 0/3 | Role for PB2 and HA to confer efficient transmission |
| HA, NA, PB1 | 0/3 | |
| HA, NA, PB2 | 3/3 | |
| HA, PB2 | 3/3 | |
| All but PB2 | 0/3 | PB2 necessary but not sufficient for transmission |
| PB2 | 1/3 | |
| All, PB2 K627E mutation | 1/5 | Role for 627K mutation |
a
Recombinant viruses bearing gene segments from the reconstructed 1918 virus on background of avian H1N1 virus (A/duck/New York/15024–21/1996).
b
Respiratory droplet transmissibility of recombinant viruses in the ferret model (number of contact ferrets with detectable virus in nasal wash specimens and seroconversion to homologous virus/total number of contact ferrets). Data previously published in (Belser et al., 2010; Tumpey et al., 2007; Van Hoeven et al., 2009b).