Table 2.
Average water and vanadium consumption in rats following perinatal exposure to sodium metavanadate (V5+) via drinking water
| Exposure Concentration (mg/L) |
Water Consumption (g/kg body weight/day)a |
Dose (mg sodium metavanadate/kg body weight/day)b |
Water Consumption (g/animal/day)a |
Vanadium concentration in exposure solution (mg/L)c |
Vanadium Consumption (mg/day)d |
|---|---|---|---|---|---|
| Male | |||||
| 0 | 56.3 ± 3.2** | 0 | 25.7 | 0 | 0 |
| 31.3 | 59.6 ± 1.9 | 1.9 ± 0.1 | 27.0 | 12.8 | 0.346 |
| 62.5 | 57.0 ± 1.6 | 3.6 ± 0.1 | 26.2 | 25.6 | 0.671 |
| 125 | 56.5 ± 2.3 | 7.1 ± 0.3 | 23.8 | 51.3 | 1.22 |
| 250 | 45.5 ± 1.7* | 11.4 ± 0.4 | 18.7 | 102.5 | 1.92 |
| 500 | 44.8 ± 0.8** | 22.4 ± 0.4 | 15.0 | 205 | 3.08 |
| Female | |||||
| 0 | 78.2 ± 2.1** | 0 | 20.8 | 0 | 0 |
| 31.3 | 80.3 ± 9.0 | 2.5 ± 0.3 | 22.7 | 12.8 | 0.291 |
| 62.5 | 76.8 ± 5.4 | 4.8 ± 0.3 | 20.5 | 25.6 | 0.525 |
| 125 | 76.6 ± 3.2 | 9.6 ± 0.4 | 20.1 | 51.3 | 1.03 |
| 250 | 55.4 ± 2.8* | 13.8 ± 0.7 | 15.0 | 102.5 | 1.54 |
| 500 | 54.1 ± 3.9* | 27.0 ± 1.9 | 12.7 | 205 | 2.60 |
Group average water consumption for all study animals (n=3-7 per exposure group) at the end of study (PND 112-119) are given as g/kg body weight/day or g/animal/day (CEBS Table I07)
Values given are group averages estimated from water consumption and subsequently the vanadyl sulfate consumption and animal body weights using data from the final week of study (PND105-112) (CEBS Table I08)
Calculated using exposure concentration and 41% (w/w) vanadium in sodium metavanadate
Calculated as vanadium concentration (mg/L) *water consumed (g/animal/day) and a solution density of 1 g/mL
Statistically significant at P <= 0.05
Statistically significant at P <= 0.01. Statistical significance for a treatment group indicates a significant pairwise test compared to the vehicle control group. Statistical significance for a control group indicates a significant trend test