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. Author manuscript; available in PMC: 2022 Apr 25.
Published in final edited form as: Curr Biol. 2022 Feb 8;32(6):1247–1261.e6. doi: 10.1016/j.cub.2022.01.034

Figure 6. Model for mitosis in Naegleria.

Figure 6.

(A) During prophase in Naegleria, bundles of microtubules form around a hollow sphere of DNA (magenta), which surrounds the single, round nucleolus (blue). In early metaphase, the DNA condenses, the nucleolus begins to divide, and the microtubule bundles (light green) organize into a hollow, twisted barrel shape. In late metaphase, the DNA is further condensed, and the nucleolus resolves into two distinct spheres. A secondary set of microtubules forms in the equatorial region (dark green) adjacent to the primary bundles. During anaphase/telophase, the DNA is segregated to the two ends of the spindle and the spindle elongates. See text for details.

(B) Insets show different possible mechanisms for chromosome separation in anaphase A (left) and anaphase B (right).