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. 2021 Jul 9;11(39):24232–24237. doi: 10.1039/d1ra03559b

The cyanidation of aromatic aldehydes with different proportions of water.

graphic file with name d1ra03559b-u2.jpg
Compound HCOOH/H2O (%) Time (h) Yielda (%)
1b 60 : 40 6 56
50 : 50 12
2b 60 : 40 6 78
50 : 50 12 75
40 : 60 24 61
30 : 70 36 52
20 : 80 48
3b 60 : 40 6 78
50 : 50 12 70
40 : 60 24 51
30 : 70 36
4b 60 : 40 6 91
50 : 50 12 67
40 : 60 24
5b 60 : 40 6 77
50 : 50 12 77
40 : 60 24 56
30 : 70 36 50
20 : 80 48
8b 60 : 40 6 86
50 : 50 12 85
40 : 60 24 79
30 : 70 36 52
20 : 80 48
20b 60 : 40 6 70
50 : 50 12 65
40 : 60 24 56
30 : 70 36
21b 60 : 40 6 82
50 : 50 12 80
40 : 60 24 69
30 : 70 36
25b 60 : 40 6 56
50 : 50 12 38
40 : 60 24
a

Yield of crude products. —: raw material is not well dissolved and the yield is lower than 30%, so it is regarded as no reaction.